Pub. Date : 2018 Jul
PMID : 29551335
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Increasing intracellular calcium synergized both LPS- and Pam3CSK4-induced IL-1alpha protein production. | Calcium | interleukin 1 alpha | Homo sapiens |
| 2 | Accordingly, blocking calcium signaling and calpain activity strongly suppressed IL-1alpha protein expression. | Calcium | interleukin 1 alpha | Homo sapiens |
| 3 | This study improves understanding of the complex mechanisms regulating IL-1alpha protein expression in hRPE cells by demonstrating that TLR4 and TLR2 stimulation and exposure to IL-1beta, ER stress and intracellular calcium all induce hRPE cells to produce intracellular IL-1alpha, which is negatively regulated by the PI3K/Akt pathway. | Calcium | interleukin 1 alpha | Homo sapiens |