Title : The kinetic analysis of the N-methylation of 4-phenylpyridine by nicotinamide N-methyltransferase: Evidence for a novel mechanism of substrate inhibition.

Pub. Date : 2018 May

PMID : 29549048






1 Functional Relationships(s)
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1 Although the Km for 4-phenylpyridine was similar to that reported for nicotinamide, its kcat of 9.3 x 10-5 +- 2 x 10-5 s-1 and specificity constant, kcat/Km, of 0.8 +- 0.8 s-1 M-1 were less than 0.15% of the respective values for nicotinamide, demonstrating that 4-phenylpyridine is a poor substrate for NNMT. Niacinamide nicotinamide N-methyltransferase Homo sapiens