Pub. Date : 2018 Mar 13
PMID : 29540733
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Glutamine is mainly metabolized through the glutaminolysis pathway and our previous report indicated that CtBP increases GDH activity and promotes glutaminolysis through repressing the expression of SIRT4, a well-known mitochondrion-located factor that inhibits glutaminolysis pathway. | ctbp | glutamate dehydrogenase 1 | Homo sapiens |
| 2 | CtBP is known to be a sensor of intracellular metabolic status; we thus hypothesized that a consensus CtBP-SIRT4-GDH axis may mediate the crosstalk between glycolysis and glutaminolysis. | ctbp | glutamate dehydrogenase 1 | Homo sapiens |
| 3 | CtBP is known to be a sensor of intracellular metabolic status; we thus hypothesized that a consensus CtBP-SIRT4-GDH axis may mediate the crosstalk between glycolysis and glutaminolysis. | ctbp | glutamate dehydrogenase 1 | Homo sapiens |
| 4 | Low level of glucose supply was found to decrease GDH activity via blocking CtBP dimerization. | ctbp | glutamate dehydrogenase 1 | Homo sapiens |
| 5 | Consistently, the CtBP dimerization inhibitor MTOB mimicked low glucose effects on SIRT4 expression, and GDH activity suggest that CtBP requires high glucose supply to act as a suppressor of SIRT4 gene. | ctbp | glutamate dehydrogenase 1 | Homo sapiens |
| 6 | In conclusion, we propose that a general molecular pathway composed by CtBP-SIRT4-GDH coordinating the metabolism of glucose and glutamine in cancer cells. | ctbp | glutamate dehydrogenase 1 | Homo sapiens |