Title : Metformin inhibits inflammatory signals in the gut by controlling AMPK and p38 MAP kinase activation.

Pub. Date : 2018 Jun 15

PMID : 29540537






1 Functional Relationships(s)
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1 Expression of active form of AMP-activated protein kinase was reduced in inflammatory bowel disease patients and treatment of mucosal cells of such patients with metformin enhanced AMP-activated protein kinase activation and reduced p38 MAP kinase activation, thereby inhibiting interleukin-6 expression. Metformin interleukin 6 Homo sapiens