Pub. Date : 2018 Jun
PMID : 29534875
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Esculetin suppresses tumor growth and metastasis by targeting Axin2/E-cadherin axis in colorectal cancer. | esculetin | cadherin 1 | Mus musculus |
| 2 | Here, esculetin (ES), a coumarin, was found to have the most potential effects on both beta-catenin-responsive transcriptional and E-cadherin promoter activities. | esculetin | cadherin 1 | Mus musculus |
| 3 | Here, esculetin (ES), a coumarin, was found to have the most potential effects on both beta-catenin-responsive transcriptional and E-cadherin promoter activities. | esculetin | cadherin 1 | Mus musculus |
| 4 | Mechanistically, Axin2 suppression by ES contributed to E-cadherin-mediated Wnt signaling inhibition. | esculetin | cadherin 1 | Mus musculus |
| 5 | Collectively, these findings suggest that targeting the Axin2/E-cadherin axis by ES may be an attractive therapeutic strategy for the treatment of metastatic CRC. | esculetin | cadherin 1 | Mus musculus |