Title : Esculetin suppresses tumor growth and metastasis by targeting Axin2/E-cadherin axis in colorectal cancer.

Pub. Date : 2018 Jun

PMID : 29534875






5 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Esculetin suppresses tumor growth and metastasis by targeting Axin2/E-cadherin axis in colorectal cancer. esculetin cadherin 1 Mus musculus
2 Here, esculetin (ES), a coumarin, was found to have the most potential effects on both beta-catenin-responsive transcriptional and E-cadherin promoter activities. esculetin cadherin 1 Mus musculus
3 Here, esculetin (ES), a coumarin, was found to have the most potential effects on both beta-catenin-responsive transcriptional and E-cadherin promoter activities. esculetin cadherin 1 Mus musculus
4 Mechanistically, Axin2 suppression by ES contributed to E-cadherin-mediated Wnt signaling inhibition. esculetin cadherin 1 Mus musculus
5 Collectively, these findings suggest that targeting the Axin2/E-cadherin axis by ES may be an attractive therapeutic strategy for the treatment of metastatic CRC. esculetin cadherin 1 Mus musculus