Pub. Date : 2018 Apr
PMID : 29529529
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Recent research has outlined that Dimethyl Fumarate (DMF) functions as a gene regulator via multiple pathways, critical among which is the NRF2 cytoprotective cascade. | Dimethyl Fumarate | NFE2 like bZIP transcription factor 2 | Homo sapiens |
| 2 | Recent research has outlined that Dimethyl Fumarate (DMF) functions as a gene regulator via multiple pathways, critical among which is the NRF2 cytoprotective cascade. | Dimethyl Fumarate | NFE2 like bZIP transcription factor 2 | Homo sapiens |
| 3 | It is our hypothesis that while the NRF2-KEAP1 inhibitory complex is reported the main pharmacological target for DMF"s NRF dependent functions, no study to date has explored the effects of DMF on DJ-1"s expression, and vice-versa, the possibility of a regulatory inadequacy in the upstream, oxidant-responsive DJ-1 activator of the NRF2 cascade. | Dimethyl Fumarate | NFE2 like bZIP transcription factor 2 | Homo sapiens |