Title : Secretin is an enterogastrone in humans.

Pub. Date : 1987 May

PMID : 2952476






5 Functional Relationships(s)
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1 We studied in humans the effect of exogenous secretin in a physiological dose on gastric acid secretion stimulated by pentagastrin and postprandial plasma gastrin concentration. Pentagastrin secretin Homo sapiens
2 Intravenous secretin in a dose of 5.6 pmol/kg/hr significantly inhibited the gastric acid output stimulated by intravenous pentagastrin in a dose of 160 pmol/kg/hr, from 11.25 +/- 1.5 to 5.99 +/- 1.34 meq/hr while lower dose of intravenous secretin (2.8 pmol/kg/hr) failed to inhibit the gastric acid output stimulated by the same dose of pentagastrin. Pentagastrin secretin Homo sapiens
3 Intravenous secretin in a dose of 5.6 pmol/kg/hr significantly inhibited the gastric acid output stimulated by intravenous pentagastrin in a dose of 160 pmol/kg/hr, from 11.25 +/- 1.5 to 5.99 +/- 1.34 meq/hr while lower dose of intravenous secretin (2.8 pmol/kg/hr) failed to inhibit the gastric acid output stimulated by the same dose of pentagastrin. Pentagastrin secretin Homo sapiens
4 Intravenous secretin in a dose of 5.6 pmol/kg/hr significantly inhibited the gastric acid output stimulated by intravenous pentagastrin in a dose of 160 pmol/kg/hr, from 11.25 +/- 1.5 to 5.99 +/- 1.34 meq/hr while lower dose of intravenous secretin (2.8 pmol/kg/hr) failed to inhibit the gastric acid output stimulated by the same dose of pentagastrin. Pentagastrin secretin Homo sapiens
5 However, the lower dose of intravenous secretin (2.8 pmol/kg/hr) inhibited the gastric acid output significantly from 8.78 +/- 1.21 to 6.37 +/- 1.62 meq/hr when gastric secretion was stimulated by the lower dose of pentagastrin (80 pmol/kg/hr). Pentagastrin secretin Homo sapiens