Title : Heme oxygenase-1/carbon monoxide axis suppresses transforming growth factor-β1-induced growth inhibition by increasing ERK1/2-mediated phosphorylation of Smad3 at Thr-179 in human hepatocellular carcinoma cell lines.

Pub. Date : 2018 Apr 6

PMID : 29524413






3 Functional Relationships(s)
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1 Heme oxygenase-1/carbon monoxide axis suppresses transforming growth factor-beta1-induced growth inhibition by increasing ERK1/2-mediated phosphorylation of Smad3 at Thr-179 in human hepatocellular carcinoma cell lines. Threonine mitogen-activated protein kinase 3 Homo sapiens
2 Additional experiments revealed that HO-1/CO axis selectively induces phosphorylation of Smad3 at Thr-179 residue in the linker region through activation of extracellular signal-activated kinase (ERK) 1/2. Threonine mitogen-activated protein kinase 3 Homo sapiens
3 These findings for the first time demonstrate that HO-1/CO axis confer resistance of HCC cells to TGF-beta growth inhibitory signal by increasing Smad3 phosphorylation at Thr-179 via ERK1/2 pathway. Threonine mitogen-activated protein kinase 3 Homo sapiens