Title : LncRNA H19 targets miR-22 to modulate H2 O2 -induced deregulation in nucleus pulposus cell senescence, proliferation, and ECM synthesis through Wnt signaling.

Pub. Date : 2018 Jun

PMID : 29520849






5 Functional Relationships(s)
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1 LncRNA H19 targets miR-22 to modulate H2 O2 -induced deregulation in nucleus pulposus cell senescence, proliferation, and ECM synthesis through Wnt signaling. Hydrogen Peroxide H19 imprinted maternally expressed transcript Homo sapiens
2 Herein, we investigated the detailed function and mechanism of H19, one of the most up-regulated lncRNAs in IDD specimens, in H2 O2 -induced cell senescence model in NPCs. Hydrogen Peroxide H19 imprinted maternally expressed transcript Homo sapiens
3 H19 could accelerate H2 O2 -induced degenerative changes by promoting cell senescence, increasing ADAMTS-5 and MMPs protein levels and Collagen I content, as well as suppressing NPC proliferation through activating Wnt/beta-catenin signaling. Hydrogen Peroxide H19 imprinted maternally expressed transcript Homo sapiens
4 Taken together, H19 acts as a ceRNA to compete with LEF1 for miR-22, thus modulating downstream Wnt/beta-catenin signaling in NPCs; H19/miR-22/LEF1 might be a novel target for improving H2 O2 -induced NPC senescence and treatment for IDD. Hydrogen Peroxide H19 imprinted maternally expressed transcript Homo sapiens
5 Taken together, H19 acts as a ceRNA to compete with LEF1 for miR-22, thus modulating downstream Wnt/beta-catenin signaling in NPCs; H19/miR-22/LEF1 might be a novel target for improving H2 O2 -induced NPC senescence and treatment for IDD. Hydrogen Peroxide H19 imprinted maternally expressed transcript Homo sapiens