Title : Key Players of Cisplatin Resistance: Towards a Systems Pharmacology Approach.

Pub. Date : 2018 Mar 7

PMID : 29518977






3 Functional Relationships(s)
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1 By combining statistical methods with available gene annotations and without a previously defined hypothesis HRas, MAPK14 (p38), CCL2, DOK1 and PTK2B were identified as genes possibly relevant for cisplatin resistance. Cisplatin protein tyrosine kinase 2 beta Homo sapiens
2 HRas, p38, CCL2, DOK1, PTK2B and JNK3 were integrated into a model of resistance-associated signalling alterations describing differential gene and protein expression between cisplatin-sensitive and -resistant cells in reaction to cisplatin exposure. Cisplatin protein tyrosine kinase 2 beta Homo sapiens
3 HRas, p38, CCL2, DOK1, PTK2B and JNK3 were integrated into a model of resistance-associated signalling alterations describing differential gene and protein expression between cisplatin-sensitive and -resistant cells in reaction to cisplatin exposure. Cisplatin protein tyrosine kinase 2 beta Homo sapiens