Pub. Date : 2018 Apr
PMID : 29518743
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Andrographolide suppresses TRIF-dependent signaling of toll-like receptors by targeting TBK1. | andrographolide | TANK binding kinase 1 | Homo sapiens |
| 2 | Andrographolide attenuated ligand-independent activation of IRF3 following overexpression of TRIF, TBK1, or IRF3. | andrographolide | TANK binding kinase 1 | Homo sapiens |
| 3 | Furthermore, andrographolide inhibited TBK1 kinase activity in vitro. | andrographolide | TANK binding kinase 1 | Homo sapiens |
| 4 | These results indicate that andrographolide modulates the TRIF-dependent pathway of TLRs by targeting TBK1 and represents a potential new anti-inflammatory candidate. | andrographolide | TANK binding kinase 1 | Homo sapiens |