Pub. Date : 2018 May
PMID : 29514855
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The Novel C-terminal Truncated 90-kDa Isoform of Topoisomerase IIalpha (TOP2alpha/90) Is a Determinant of Etoposide Resistance in K562 Leukemia Cells via Heterodimerization with the TOP2alpha/170 Isoform. | Etoposide | DNA topoisomerase II alpha | Homo sapiens |
| 2 | The Novel C-terminal Truncated 90-kDa Isoform of Topoisomerase IIalpha (TOP2alpha/90) Is a Determinant of Etoposide Resistance in K562 Leukemia Cells via Heterodimerization with the TOP2alpha/170 Isoform. | Etoposide | DNA topoisomerase II alpha | Homo sapiens |
| 3 | We previously characterized a C-terminally truncated isoform (TOP2alpha/90), detectable in human leukemia K562 cells but more abundantly expressed in a clonal subline, K/VP.5, with acquired resistance to the anticancer agent etoposide. | Etoposide | DNA topoisomerase II alpha | Homo sapiens |
| 4 | Forced expression of TOP2alpha/90 in K562 cells suppressed, whereas siRNA-mediated knockdown of TOP2alpha/90 in K/VP.5 cells enhanced, etoposide-mediated DNA strand breaks compared with similarly treated cells transfected with empty vector or control siRNAs, respectively. | Etoposide | DNA topoisomerase II alpha | Homo sapiens |
| 5 | In addition, forced expression of TOP2alpha/90 in K562 cells inhibited etoposide cytotoxicity assessed by clonogenic assays. | Etoposide | DNA topoisomerase II alpha | Homo sapiens |