Title : Indoleamine 2, 3-dioxygenase Up-regulates Hypoxia-inducible Factor-1α Expression by Degrading L-tryptophan but Not Its Activity in Human Alloreactive T-cells.

Pub. Date : 2018 Feb

PMID : 29512370






1 Functional Relationships(s)
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1 For this purpose, mixed lymphocyte reaction (MLR) was performed using the IDO inhibitor 1-DL-methyl-tryptophan and the p53 inhibitor pifithrin-alpha. pifithrin tumor protein p53 Homo sapiens