Title : A STAT6 Inhibitor AS1517499 Reduces Preventive Effects of Apoptotic Cell Instillation on Bleomycin-Induced Lung Fibrosis by Suppressing PPARĪ³.

Pub. Date : 2018

PMID : 29510393






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1 A STAT6 Inhibitor AS1517499 Reduces Preventive Effects of Apoptotic Cell Instillation on Bleomycin-Induced Lung Fibrosis by Suppressing PPARgamma. Bleomycin peroxisome proliferator activated receptor gamma Mus musculus
2 Co-administration of the STAT6 inhibitor, AS1517499, reversed the enhanced PPARgamma expression and activity induced by apoptotic cell instillation after bleomycin treatment. Bleomycin peroxisome proliferator activated receptor gamma Mus musculus
3 CONCLUSION: These results indicate that prolonged STAT6 activation following one-time apoptotic cell instillation facilitates continuous PPARgamma activation, resulting in the resolution of bleomycin-induced lung inflammation and fibrosis. Bleomycin peroxisome proliferator activated receptor gamma Mus musculus