Title : GRGM-13 comprising 13 plant and animal products, inhibited oxidative stress induced apoptosis in retinal ganglion cells by inhibiting P2RX7/p38 MAPK signaling pathway.

Pub. Date : 2018 May

PMID : 29501771






2 Functional Relationships(s)
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1 Finally, we observed that P2 x 7R agonist BzATP reversed the inhibition effect of GRGM-13 on RGC-5 cell apoptosis, ROS level and p-p38 expression, while si-P2 x 7R inhibited oxidative stress-induced phosphorylation of p38. 3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate mitogen-activated protein kinase 14 Mus musculus
2 Finally, we observed that P2 x 7R agonist BzATP reversed the inhibition effect of GRGM-13 on RGC-5 cell apoptosis, ROS level and p-p38 expression, while si-P2 x 7R inhibited oxidative stress-induced phosphorylation of p38. 3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate mitogen-activated protein kinase 14 Mus musculus