Pub. Date : 2018 May 1
PMID : 29461981
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | CYP3A4 mutation causes vitamin D-dependent rickets type 3. | Vitamin D | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 2 | In vitro, the mutant CYP3A4 oxidized 1,25-dihydroxyvitamin D with 10-fold greater activity than WT CYP3A4 and 2-fold greater activity than CYP24A1, the principal inactivator of vitamin D metabolites. | Vitamin D | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 3 | In vitro, the mutant CYP3A4 oxidized 1,25-dihydroxyvitamin D with 10-fold greater activity than WT CYP3A4 and 2-fold greater activity than CYP24A1, the principal inactivator of vitamin D metabolites. | Vitamin D | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 4 | As CYP3A4 mutations have not previously been linked to rickets, these findings provide insight into vitamin D metabolism and demonstrate that accelerated inactivation of vitamin D metabolites represents a mechanism for vitamin D deficiency. | Vitamin D | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 5 | As CYP3A4 mutations have not previously been linked to rickets, these findings provide insight into vitamin D metabolism and demonstrate that accelerated inactivation of vitamin D metabolites represents a mechanism for vitamin D deficiency. | Vitamin D | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 6 | As CYP3A4 mutations have not previously been linked to rickets, these findings provide insight into vitamin D metabolism and demonstrate that accelerated inactivation of vitamin D metabolites represents a mechanism for vitamin D deficiency. | Vitamin D | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |