Title : A case of a warfarinized renal cancer patient monitored for prothrombin time-international normalized ratio during methadone introduction.

Pub. Date : 2017

PMID : 29457079






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1 When warfarin and methadone are used together, we have to consider their interaction by comparing the competitive inhibition of CYP2C9 to the induction of CYP3A4 by methadone, because CYP3A4 metabolize various drugs including oxycodone. Methadone cytochrome P450 family 2 subfamily C member 9 Homo sapiens