Title : Discovery of DSP-1053, a novel benzylpiperidine derivative with potent serotonin transporter inhibitory activity and partial 5-HT1A receptor agonistic activity.

Pub. Date : 2018 May 1

PMID : 29456112






1 Functional Relationships(s)
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1 We have previously shown that SMP-304, a serotonin uptake inhibitor with weak 5-HT1A partial agonistic activity, may act under high serotonin levels as a 5-HT1A antagonist that improves the onset of paroxetine in the rat swimming test. Paroxetine 5-hydroxytryptamine receptor 1A Rattus norvegicus