Title : Development of selective inhibitors for the treatment of rheumatoid arthritis: (R)-3-(3-(Methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)pyrrolidin-1-yl)-3-oxopropanenitrile as a JAK1-selective inhibitor.

Pub. Date : 2018 May 1

PMID : 29452839






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Compound 6 showed improved selectivity for JAK1 compared to that of tofacitinib (IC50 11, 2.4 x 102, 2.8 x 103, and 1.1 x 102 nM for JAK1, JAK2, JAK3, and TYK2, respectively). tofacitinib Janus kinase 2 Homo sapiens