Title : TNFα disrupts blood brain barrier integrity to maintain prolonged depressive-like behavior in mice.

Pub. Date : 2018 Mar

PMID : 29452218






2 Functional Relationships(s)
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1 Treatment with the GSK3 inhibitor TDZD-8 reduced inflammatory cytokine levels, increased tight junction protein levels, and reversed impaired recovery from learned helplessness, demonstrating that prolonged learned helplessness is reversible and is maintained by abnormally active GSK3. 4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione glycogen synthase kinase 3 beta Mus musculus
2 Treatment with the GSK3 inhibitor TDZD-8 reduced inflammatory cytokine levels, increased tight junction protein levels, and reversed impaired recovery from learned helplessness, demonstrating that prolonged learned helplessness is reversible and is maintained by abnormally active GSK3. 4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione glycogen synthase kinase 3 beta Mus musculus