Title : Coupling the core of the anticancer drug etoposide to an oligonucleotide induces topoisomerase II-mediated cleavage at specific DNA sequences.

Pub. Date : 2018 Mar 16

PMID : 29447373






1 Functional Relationships(s)
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1 Results indicate that OTIs can be used to direct the sites of etoposide-induced DNA cleavage mediated by topoisomerase IIalpha and topoisomerase IIbeta. Etoposide DNA topoisomerase II beta Homo sapiens