Title : Ponatinib Shows Potent Antitumor Activity in Small Cell Carcinoma of the Ovary Hypercalcemic Type (SCCOHT) through Multikinase Inhibition.

Pub. Date : 2018 Apr 15

PMID : 29440177






3 Functional Relationships(s)
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1 Ponatinib was tested for efficacy in two patient-derived xenograft (PDX) models and one cell-line xenograft model of SCCOHT.Results: The receptor tyrosine kinase (RTK) family was enriched in siRNA screen hits, with FGFRs and PDGFRs being overlapping hits between drug and siRNA screens. ponatinib ret proto-oncogene Homo sapiens
2 Ponatinib was tested for efficacy in two patient-derived xenograft (PDX) models and one cell-line xenograft model of SCCOHT.Results: The receptor tyrosine kinase (RTK) family was enriched in siRNA screen hits, with FGFRs and PDGFRs being overlapping hits between drug and siRNA screens. ponatinib ret proto-oncogene Homo sapiens
3 We further identified ponatinib as the most effective clinically approved RTK inhibitor. ponatinib ret proto-oncogene Homo sapiens