Title : Identification of UGTs and BCRP as potential pharmacokinetic determinants of the natural flavonoid alpinetin.

Pub. Date : 2019 Mar

PMID : 29436891






2 Functional Relationships(s)
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1 Glucuronidation of alpinetin was significantly correlated with glucuronidation of estradiol (an activity marker of UGT1A1), chenodeoxycholic acid (an activity marker of UGT1A3), propofol (an activity marker of UGT1A9) and 5-hydroxyrofecoxib (an activity marker of UGT2B15), confirming the important roles of UGT1A1, UGT1A3, UGT1A9 and UGT2B15 in alpinetin glucuronidation. alpinetin UDP glucuronosyltransferase family 2 member B15 Homo sapiens
2 Glucuronidation of alpinetin was significantly correlated with glucuronidation of estradiol (an activity marker of UGT1A1), chenodeoxycholic acid (an activity marker of UGT1A3), propofol (an activity marker of UGT1A9) and 5-hydroxyrofecoxib (an activity marker of UGT2B15), confirming the important roles of UGT1A1, UGT1A3, UGT1A9 and UGT2B15 in alpinetin glucuronidation. alpinetin UDP glucuronosyltransferase family 2 member B15 Homo sapiens