Title : Glycyrrhizin affects monocyte migration and apoptosis by blocking HMGB1 signaling.

Pub. Date : 2018 Apr

PMID : 29436639






3 Functional Relationships(s)
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1 GL inhibited the activation of the NF-kappaB and MAPK/ERK signaling pathways induced by HMGB1 and decreased the expression of monocyte chemoattractant protein-1 (MCP-1) and myeloid cell leukemia 1 (Mcl-1). Glycyrrhizic Acid mitogen-activated protein kinase 1 Homo sapiens
2 Taken together, the results indicated that GL may suppress the migration of monocytes and induce apoptosis to reduce systemic inflammation by blocking downstream NF-kappaB/MCP-1 and MAPK/ERK/Mcl-1 signaling pathways. Glycyrrhizic Acid mitogen-activated protein kinase 1 Homo sapiens
3 Taken together, the results indicated that GL may suppress the migration of monocytes and induce apoptosis to reduce systemic inflammation by blocking downstream NF-kappaB/MCP-1 and MAPK/ERK/Mcl-1 signaling pathways. Glycyrrhizic Acid mitogen-activated protein kinase 1 Homo sapiens