Pub. Date : 2018 Apr
PMID : 29432801
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | The inhibition assay showed that glybenclamide (a K+ efflux inhibitor that blocks NLRP3 inflammasome activation) and N-benzyloxycarbony-Val-Ala-Asp (O-methyl)-fluoromethylketone (Z-VAD-FMK; a caspase-1 inhibitor) and NLRP3 depletion with siRNAs reduced the levels of IL-1beta and IL-18 release. | Glyburide | NLR family pyrin domain containing 3 | Homo sapiens |
2 | The inhibition assay showed that glybenclamide (a K+ efflux inhibitor that blocks NLRP3 inflammasome activation) and N-benzyloxycarbony-Val-Ala-Asp (O-methyl)-fluoromethylketone (Z-VAD-FMK; a caspase-1 inhibitor) and NLRP3 depletion with siRNAs reduced the levels of IL-1beta and IL-18 release. | Glyburide | NLR family pyrin domain containing 3 | Homo sapiens |