Title : Pyk2 deficiency potentiates osteoblast differentiation and mineralizing activity in response to estrogen or raloxifene.

Pub. Date : 2018 Oct 15

PMID : 29428397






1 Functional Relationships(s)
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1 In addition we found that Pyk2-KO OBs cultured in the presence of either 17beta-estradiol (E2) or raloxifene, a SERM used for the treatment of post-menopausal osteoporosis, showed a further robust increase in alkaline phosphatase (ALP) activity and mineralization. Estradiol protein tyrosine kinase 2 beta Homo sapiens