Title : Comparison of the effects of sodium phenobarbital in wild type and humanized constitutive androstane receptor (CAR)/pregnane X receptor (PXR) mice and in cultured mouse, rat and human hepatocytes.

Pub. Date : 2018 Mar 1

PMID : 29425889






1 Functional Relationships(s)
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1 In this study, the hepatic effects of sodium phenobarbital (NaPB) were compared in male C57BL/6J wild type (WT) mice and in humanized mice, where both the mouse CAR and pregnane X receptor (PXR) have been replaced by their human counterparts (hCAR/hPXR mice). Phenobarbital N-ethylmaleimide sensitive fusion protein attachment protein beta Mus musculus