Title : Design and synthesis of new potent N,N-bis(arylalkyl)piperazine derivatives as multidrug resistance (MDR) reversing agents.

Pub. Date : 2018 Mar 10

PMID : 29421572






2 Functional Relationships(s)
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1 Two long-lasting P-gp pump modulators (9 and 10) were identified; they were able to inhibit remarkably the P-gp substrate rhodamine-123 efflux on the resistant K562/DOX cell line after 60 min. Rhodamines phosphoglycolate phosphatase Homo sapiens
2 Two long-lasting P-gp pump modulators (9 and 10) were identified; they were able to inhibit remarkably the P-gp substrate rhodamine-123 efflux on the resistant K562/DOX cell line after 60 min. Rhodamines phosphoglycolate phosphatase Homo sapiens