Title : Combination treatment of all-trans retinoic acid (ATRA) and γ-secretase inhibitor (DAPT) cause growth inhibition and apoptosis induction in the human gastric cancer cell line.

Pub. Date : 2018 Apr

PMID : 29417442






2 Functional Relationships(s)
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1 The combination of DAPT and ATRA effectively increased the proportion of apoptotic cells and the level of caspase 3/7 activities compared to single treatment. Tretinoin caspase 3 Homo sapiens
2 Moreover, augmented caspase-3 up-regulation and bcl-2 down-regulation were found following combined application of DAPT and ATRA. Tretinoin caspase 3 Homo sapiens