Title : An in-vitro cocktail assay for assessing compound-mediated inhibition of six major cytochrome P450 enzymes.

Pub. Date : 2014 Aug

PMID : 29403890






1 Functional Relationships(s)
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1 This method employed a cocktail of six probe substrates (i.e., phenacetin, amodiaquine, diclofenac, S-mephenytoin, dextromethorphan and midazolam for CYP1A2, 2C8, 2C9, 2C19, 2D6 and 3A4, respectively) as well as individual prototypical inhibitors of the six CYP enzymes in human liver microsomes under optimized incubation conditions. Phenacetin cytochrome P450 family 1 subfamily A member 2 Homo sapiens