Pub. Date : 2018 Jun
PMID : 29401586
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | PolyQ-expanded huntingtin and ataxin-3 sequester ubiquitin adaptors hHR23B and UBQLN2 into aggregates via conjugated ubiquitin. | polyglutamine | RAD23 homolog B, nucleotide excision repair protein | Homo sapiens |
| 2 | We found that polyQ-expanded Htt-N552 and Atx-3 sequester endogenous Ub adaptors, human RAD23 homolog B (hHR23B) and ubiquilin (UBQLN)-2, into inclusions. | polyglutamine | RAD23 homolog B, nucleotide excision repair protein | Homo sapiens |
| 3 | Moreover, polyQ-expanded Htt-N552 and Atx-3 reduce the protein level of xeroderma pigmentosum group C (XPC) by sequestration of hHR23B, suggesting that this process may cut down the available quantity of hHR23B and thus affect its normal function in stabilizing XPC. | polyglutamine | RAD23 homolog B, nucleotide excision repair protein | Homo sapiens |
| 4 | Moreover, polyQ-expanded Htt-N552 and Atx-3 reduce the protein level of xeroderma pigmentosum group C (XPC) by sequestration of hHR23B, suggesting that this process may cut down the available quantity of hHR23B and thus affect its normal function in stabilizing XPC. | polyglutamine | RAD23 homolog B, nucleotide excision repair protein | Homo sapiens |
| 5 | PolyQ-expanded huntingtin and ataxin-3 sequester ubiquitin adaptors hHR23B and UBQLN2 into aggregates via conjugated ubiquitin. | polyglutamine | RAD23 homolog B, nucleotide excision repair protein | Homo sapiens |