Title : Ticagrelor attenuates myocardial ischaemia-reperfusion injury possibly through downregulating galectin-3 expression in the infarct area of rats.

Pub. Date : 2018 Jun

PMID : 29381821






3 Functional Relationships(s)
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1 It remains unknown whether the cardioprotective effects of ticagrelor are also mediated by modulating myocardial galectin-3 expression. Ticagrelor galectin 3 Rattus norvegicus
2 RESULTS: Our results showed that ticagrelor treatment significantly reduced IA/AAR ratio at 3 and 7 days post I/R, downregulated mRNA and protein expression of galectin-3, as well as mRNA expression of TNF-alpha and IL-6 in infarct area at 24 h, 3 and 7 days post I/R. Ticagrelor galectin 3 Rattus norvegicus
3 CONCLUSIONS: Our results suggest that the cardioprotective effects of ticagrelor might partly be mediated by downregulating galectin-3 expression in infarct area in this rat model of myocardial I/R injury. Ticagrelor galectin 3 Rattus norvegicus