Title : Nudt19 is a renal CoA diphosphohydrolase with biochemical and regulatory properties that are distinct from the hepatic Nudt7 isoform.

Pub. Date : 2018 Mar 16

PMID : 29378847






2 Functional Relationships(s)
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1 Two mammalian Nudix hydrolases, Nudt19 and Nudt7, degrade CoA in vitro Nudt19 and Nudt7 possess conserved Nudix and CoA signature sequences and specifically hydrolyze the diphosphate bond of free CoA and acyl-CoAs to form 3",5"-ADP and 4"-(acyl)phosphopantetheine. nudix nudix hydrolase 19 Homo sapiens
2 Two mammalian Nudix hydrolases, Nudt19 and Nudt7, degrade CoA in vitro Nudt19 and Nudt7 possess conserved Nudix and CoA signature sequences and specifically hydrolyze the diphosphate bond of free CoA and acyl-CoAs to form 3",5"-ADP and 4"-(acyl)phosphopantetheine. nudix nudix hydrolase 19 Homo sapiens