Pub. Date : 2018 Apr 5
PMID : 29378196
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Chronic administration of either GnRH agonists or antagonists leads to suppression of testosterone production in the testes via either downregulation or direct blockade of the GnRH receptor in the pituitary, respectively. | Testosterone | gonadotropin releasing hormone 1 | Rattus norvegicus |
| 2 | Chronic administration of kisspeptin analogs has more recently been shown to lead to testosterone suppression via desensitization of GnRH neurons in the hypothalamus and an optimized kisspeptin analog, TAK-448, was proven effective in a small phase 1 trial. | Testosterone | gonadotropin releasing hormone 1 | Rattus norvegicus |