Title : Oxidant injury of cells. DNA strand-breaks activate polyadenosine diphosphate-ribose polymerase and lead to depletion of nicotinamide adenine dinucleotide.

Pub. Date : 1986 Apr

PMID : 2937805






1 Functional Relationships(s)
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1 Poly-ADP-ribose polymerase, a nuclear enzyme associated with DNA damage and repair, which catalyzes conversion of NAD to nicotinamide and protein-bound poly-ADP-ribose, was activated by exposure of the cells to concentrations of 40 microM H2O2 or higher. Niacinamide poly (ADP-ribose) polymerase family, member 1 Mus musculus