Pub. Date : 2018 Apr 25
PMID : 29373314
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Duox2 belongs to the large family of NADPH-oxidase enzymes that are implicated in immune response, vasoregulation, hormone synthesis, cell growth and differentiation via the regulated synthesis of H2O2 and reactive oxygen species. | Hydrogen Peroxide | dual oxidase 2 | Homo sapiens |
| 2 | Now, using the CRISPR/Cas9-mediated genome editing we demonstrate that the extreme C-terminal region of Duox2 is required for PDGF-stimulated activity of Duox2 and H2O2 production. | Hydrogen Peroxide | dual oxidase 2 | Homo sapiens |
| 3 | We found that nonsense substitution of the last 23 amino acids in Duox2 results in complete loss of PDGF stimulation of intracellular H2O2 and fibroblast migration, yet these mutations have no effects on the expression of Duox2 and other NADPH-oxidases in cells. | Hydrogen Peroxide | dual oxidase 2 | Homo sapiens |