Pub. Date : 2017 Dec 26
PMID : 29371922
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We investigate the effect of CagA on etoposide-induced apoptosis in gastric cancer cells to elucidate whether CagA play a role in gastric carcinogenesis via impairing DNA damage-dependent apoptosis. | Etoposide | S100 calcium binding protein A8 | Homo sapiens |
| 2 | In the presence of etoposide, viability of parental AGS cells was decreased in a time-and dose-dependent manner, whereas CagA-expressing AGS cells were less susceptible to etoposide induced cell-killing effect. | Etoposide | S100 calcium binding protein A8 | Homo sapiens |
| 3 | In the presence of etoposide, viability of parental AGS cells was decreased in a time-and dose-dependent manner, whereas CagA-expressing AGS cells were less susceptible to etoposide induced cell-killing effect. | Etoposide | S100 calcium binding protein A8 | Homo sapiens |
| 4 | Suppression of etoposide-induced apoptosis was shown in CagA-expressing but not in parental AGS cells by DNA fragmentation, cell cycle, and annexin-V assays. | Etoposide | S100 calcium binding protein A8 | Homo sapiens |
| 5 | This inhibitory effect of etoposide-induced apoptosis conferred by CagA was also demonstrated in SCM1 and MKN45 gastric cancer cell lines, with two additional chemotherapeutics, 5-FU and cisplatin. | Etoposide | S100 calcium binding protein A8 | Homo sapiens |
| 6 | The effect of Akt activation on inhibition of etoposide-induced cytotoxicity by CagA was also evaluated. | Etoposide | S100 calcium binding protein A8 | Homo sapiens |
| 7 | Enhancement of etoposide cytotoxicity by a PI-3-kinase inhibitor, LY294002, was evident in parental but was attenuated in CagA-expressing AGS cells. | Etoposide | S100 calcium binding protein A8 | Homo sapiens |