Pub. Date : 2018 Jan 22
PMID : 29358575
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Pathological hydrogen peroxide triggers the fibrillization of wild-type SOD1 via sulfenic acid modification of Cys-111. | Hydrogen Peroxide | superoxide dismutase 1 | Homo sapiens |
| 2 | However, how SOD1-catalyzed reaction product hydrogen peroxide affects amyloid formation of SOD1 and TDP-43 remains elusory. | Hydrogen Peroxide | superoxide dismutase 1 | Homo sapiens |
| 3 | However, how SOD1-catalyzed reaction product hydrogen peroxide affects amyloid formation of SOD1 and TDP-43 remains elusory. | Hydrogen Peroxide | superoxide dismutase 1 | Homo sapiens |
| 4 | In this paper, we demonstrate that H2O2 at pathological concentrations triggers the fibrillization of wild-type SOD1 both in vitro and in SH-SY5Y cells. | Hydrogen Peroxide | superoxide dismutase 1 | Homo sapiens |
| 5 | Using an anti-dimedone antibody that detects sulfenic acid modification of proteins, we found that Cys-111 in wild-type SOD1 is oxidized to C-SOH by pathological concentration of H2O2, followed by the formation of sulfenic acid modified SOD1 oligomers. | Hydrogen Peroxide | superoxide dismutase 1 | Homo sapiens |
| 6 | Thus, we propose that H2O2 at pathological concentrations triggers the fibrillization of wild-type SOD1 and subsequently induces SOD1 toxicity and TDP-43 toxicity in neuronal cells via sulfenic acid modification of Cys-111 in SOD1. | Hydrogen Peroxide | superoxide dismutase 1 | Homo sapiens |
| 7 | Thus, we propose that H2O2 at pathological concentrations triggers the fibrillization of wild-type SOD1 and subsequently induces SOD1 toxicity and TDP-43 toxicity in neuronal cells via sulfenic acid modification of Cys-111 in SOD1. | Hydrogen Peroxide | superoxide dismutase 1 | Homo sapiens |
| 8 | Thus, we propose that H2O2 at pathological concentrations triggers the fibrillization of wild-type SOD1 and subsequently induces SOD1 toxicity and TDP-43 toxicity in neuronal cells via sulfenic acid modification of Cys-111 in SOD1. | Hydrogen Peroxide | superoxide dismutase 1 | Homo sapiens |
| 9 | These findings can explain how H2O2 at pathologic concentrations regulates the misfolding and toxicity of SOD1 and TDP-43 associated with ALS, and suggest that sulfenic acid modification of wild-type SOD1 should play pivotal roles in the pathogenesis of sporadic ALS. | Hydrogen Peroxide | superoxide dismutase 1 | Homo sapiens |
| 10 | These findings can explain how H2O2 at pathologic concentrations regulates the misfolding and toxicity of SOD1 and TDP-43 associated with ALS, and suggest that sulfenic acid modification of wild-type SOD1 should play pivotal roles in the pathogenesis of sporadic ALS. | Hydrogen Peroxide | superoxide dismutase 1 | Homo sapiens |