Title : Zn2+-induced disruption of neuronal mitochondrial function: Synergism with Ca2+, critical dependence upon cytosolic Zn2+ buffering, and contributions to neuronal injury.

Pub. Date : 2018 Apr

PMID : 29355498






2 Functional Relationships(s)
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1 While brief (5 min) neuronal depolarization (to activate VSCC) in the presence of 300 muM Zn2+ causes substantial delayed neurodegeneration, it only mildly impacts acute mitochondrial function, raising questions as to contributions of Zn2+-induced mitochondrial dysfunction to neuronal injury. Zinc latexin Homo sapiens
2 Mild disruption of cytosolic Zn2+ buffering-while having little effects alone-markedly enhanced mitochondrial Zn2+ accumulation and dysfunction (including loss of Psim, ROS generation, swelling and respiratory inhibition) caused by relatively low (10-50 muM) Zn2+ with high K+. Zinc latexin Homo sapiens