Pub. Date : 2018 Apr
PMID : 29341316
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Deferoxamine promotes mesenchymal stem cell homing in noise-induced injured cochlea through PI3K/AKT pathway. | Deferoxamine | AKT serine/threonine kinase 1 | Rattus norvegicus |
| 2 | Deferoxamine (DFO) can induce the Akt activation, and phosphorylation status of AKT (p-AKT) upregulates CXC chemokine receptor-4 (CXCR4) expression. | Deferoxamine | AKT serine/threonine kinase 1 | Rattus norvegicus |
| 3 | Deferoxamine (DFO) can induce the Akt activation, and phosphorylation status of AKT (p-AKT) upregulates CXC chemokine receptor-4 (CXCR4) expression. | Deferoxamine | AKT serine/threonine kinase 1 | Rattus norvegicus |
| 4 | Deferoxamine (DFO) can induce the Akt activation, and phosphorylation status of AKT (p-AKT) upregulates CXC chemokine receptor-4 (CXCR4) expression. | Deferoxamine | AKT serine/threonine kinase 1 | Rattus norvegicus |
| 5 | Deferoxamine (DFO) can induce the Akt activation, and phosphorylation status of AKT (p-AKT) upregulates CXC chemokine receptor-4 (CXCR4) expression. | Deferoxamine | AKT serine/threonine kinase 1 | Rattus norvegicus |
| 6 | Deferoxamine (DFO) can induce the Akt activation, and phosphorylation status of AKT (p-AKT) upregulates CXC chemokine receptor-4 (CXCR4) expression. | Deferoxamine | AKT serine/threonine kinase 1 | Rattus norvegicus |
| 7 | Deferoxamine (DFO) can induce the Akt activation, and phosphorylation status of AKT (p-AKT) upregulates CXC chemokine receptor-4 (CXCR4) expression. | Deferoxamine | AKT serine/threonine kinase 1 | Rattus norvegicus |
| 8 | We examined whether DFO can enhance mesenchymal stem cells (MSCs) homing in noise-induced damaged cochlea by PI3K/AKT dependent mechanism. | Deferoxamine | AKT serine/threonine kinase 1 | Rattus norvegicus |
| 9 | RESULTS: Deferoxamine increased P-AKT, HIF-1alpha and CXCR4 expression in MSCs compared to non-treated cells. | Deferoxamine | AKT serine/threonine kinase 1 | Rattus norvegicus |
| 10 | CONCLUSIONS: Pre-conditioning of MSCs by DFO before transplantation can improve stem cell homing in the damaged cochlea through PI3K/AKT pathway activation. | Deferoxamine | AKT serine/threonine kinase 1 | Rattus norvegicus |