Title : Azathioprine suppresses the mixed lymphocyte reaction of patients with Lesch-Nyhan syndrome.

Pub. Date : 1985 Nov

PMID : 2934083






2 Functional Relationships(s)
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1 When both stimulator and responder lymphocytes in the MLR were HGPRT deficient, azathioprine (36 microM) was much more inhibitory than 6-MP (100 microM). Azathioprine hypoxanthine phosphoribosyltransferase 1 Homo sapiens
2 The difference in inhibitory activity between azathioprine and 6-MP was reduced when normal stimulator lymphocytes were cultured with HGPRT deficient responder lymphocytes in the MLR. Azathioprine hypoxanthine phosphoribosyltransferase 1 Homo sapiens