Title : Characterization of an Hsp90-Independent Interaction between Co-Chaperone p23 and Transcription Factor p53.

Pub. Date : 2018 Feb 13

PMID : 29334217






3 Functional Relationships(s)
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1 Using a combination of nuclear magnetic resonance (NMR) titration, isothermal titration calorimetry, fluorescence anisotropy, and native agarose gel electrophoresis, we have identified a direct interaction between the p53 DBD and Hsp90 co-chaperone p23 that occurs in the absence of Hsp90. Sepharose tumor protein p53 Homo sapiens
2 We show by NMR and native agarose gel electrophoresis that a p53-specific double-stranded DNA sequence competes successfully with p23 for binding to the p53 DBD. Sepharose tumor protein p53 Homo sapiens
3 We show by NMR and native agarose gel electrophoresis that a p53-specific double-stranded DNA sequence competes successfully with p23 for binding to the p53 DBD. Sepharose tumor protein p53 Homo sapiens