Title : An in silico approach in predicting the possible mechanism involving restoration of wild-type p53 functions by small molecular weight compounds in tumor cells expressing R273H mutant p53.

Pub. Date : 2017

PMID : 29333130






2 Functional Relationships(s)
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1 Here, curcumin, flavokawain B, and alpinetin were docked against the crystal structure of R273H mutant p53 in silico. Curcumin tumor protein p53 Homo sapiens
2 Consequently, all the compounds bind to the cavity of R273H mutant p53 with a dissociation constant estimated to have 36.57, 70.77, and 75.11 microM for curcumin, flavokawain B, and alpinetin, respectively. Curcumin tumor protein p53 Homo sapiens