Title : Cetuximab enhances cisplatin-induced endoplasmic reticulum stress-associated apoptosis in laryngeal squamous cell carcinoma cells by inhibiting expression of TXNDC5.

Pub. Date : 2018 Mar

PMID : 29328423






1 Functional Relationships(s)
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1 Cisplatin and cetuximab demonstrated a combinatorial effect on increasing the levels of CHOP, caspase-3 activity and apoptosis, which was largely eliminated by overexpression of TXNDC5 or a reactive oxygen species (ROS) scavenger/antagonist. Reactive Oxygen Species DNA damage inducible transcript 3 Homo sapiens