Title : Microcirculation improvement after short-term infusion of vasopressin in septic shock is dependent on noradrenaline.

Pub. Date : 2017 Dec

PMID : 29319721






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1 Microcirculation improvement after short-term infusion of vasopressin in septic shock is dependent on noradrenaline. Norepinephrine arginine vasopressin Homo sapiens
2 The noradrenaline dose was significantly reduced after vasopressin (p=0.001) and was higher both at baseline and during vasopressin infusion in the responders than in the non-responders. Norepinephrine arginine vasopressin Homo sapiens
3 The noradrenaline dose was significantly reduced after vasopressin (p=0.001) and was higher both at baseline and during vasopressin infusion in the responders than in the non-responders. Norepinephrine arginine vasopressin Homo sapiens
4 For patients using a noradrenaline dose higher than 0.38 mcg/kg/min, the probability that microcirculatory perfusion would be improved with vasopressin was 53% (sensitivity 78%, specificity 77%). Norepinephrine arginine vasopressin Homo sapiens
5 CONCLUSIONS: In patients with septic shock for no longer than 48 h, administration of vasopressin is likely to result in an improvement in microcirculation when the baseline noradrenaline dose is higher than 0.38 mcg/kg/min. Norepinephrine arginine vasopressin Homo sapiens