Pub. Date : 2017 Dec
PMID : 29285098
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Aspirin suppresses TNF-alpha-induced MMP-9 expression via NF-kappaB and MAPK signaling pathways in RAW264.7 cells. | Aspirin | tumor necrosis factor | Mus musculus |
| 2 | The present study aimed to investigate the pharmacological effects of aspirin on tumor necrosis factor-alpha (TNF-alpha)-induced MMP-9 expression and the underlying molecular mechanisms in murine macrophage RAW264.7 cells. | Aspirin | tumor necrosis factor | Mus musculus |
| 3 | The present study aimed to investigate the pharmacological effects of aspirin on tumor necrosis factor-alpha (TNF-alpha)-induced MMP-9 expression and the underlying molecular mechanisms in murine macrophage RAW264.7 cells. | Aspirin | tumor necrosis factor | Mus musculus |
| 4 | Furthermore, subsequent to inhibition of the MAPK pathway by specific inhibitors (PD98059, SB203580 and SP600125), the expression of MMP-9 was reduced, indicating that the inhibitory effect of aspirin on MMP-9 in TNF-alpha-treated RAW264.7 cells may be, at least in part, through suppression of NF-kappaB activation and the MAPK pathway. | Aspirin | tumor necrosis factor | Mus musculus |