Title : Human P450 CYP17A1: Control of Substrate Preference by Asparagine 202.

Pub. Date : 2018 Feb 6

PMID : 29283561






1 Functional Relationships(s)
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1 Replacement of asparagine 202 with serine completely reverses the preference of CYP17A1, more than doubling the rate of turnover of the OHPROG to androstenedione reaction and substantially decreasing the rate of formation of dehydroepiandrosterone from OHPREG. Androstenedione cytochrome P450 family 17 subfamily A member 1 Homo sapiens