Title : Reduction and Scavenging of Chemically Reactive Drug Metabolites by NAD(P)H:Quinone Oxidoreductase 1 and NRH:Quinone Oxidoreductase 2 and Variability in Hepatic Concentrations.

Pub. Date : 2018 Feb 19

PMID : 29281794






2 Functional Relationships(s)
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1 Using recombinant NQO1, we showed that low nM concentrations of NQO1 are sufficient to reduce synthetic amodiaquine and carbamazepine quinone-like metabolites in vitro. Amodiaquine NAD(P)H quinone dehydrogenase 1 Homo sapiens
2 Using recombinant NQO1, we showed that low nM concentrations of NQO1 are sufficient to reduce synthetic amodiaquine and carbamazepine quinone-like metabolites in vitro. Amodiaquine NAD(P)H quinone dehydrogenase 1 Homo sapiens