Title : Specific Inhibition of the Bifunctional Farnesyl/Geranylgeranyl Diphosphate Synthase in Malaria Parasites via a New Small-Molecule Binding Site.

Pub. Date : 2018 Feb 15

PMID : 29276048






1 Functional Relationships(s)
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1 Unfortunately, current bisphosphonate drugs that inhibit FPPS and GGPPS enzymes by acting as a diphosphate substrate analog show poor bioavailability and selectivity for PfFPPS/GGPPS. Diphosphates farnesyl diphosphate synthase Homo sapiens