Pub. Date : 2018 Feb 15
PMID : 29276048
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Unfortunately, current bisphosphonate drugs that inhibit FPPS and GGPPS enzymes by acting as a diphosphate substrate analog show poor bioavailability and selectivity for PfFPPS/GGPPS. | Diphosphonates | farnesyl diphosphate synthase | Homo sapiens |
2 | We identified a new non-bisphosphonate compound, MMV019313, which is highly selective for PfFPPS/GGPPS and showed no activity against human FPPS or GGPPS. | Diphosphonates | farnesyl diphosphate synthase | Homo sapiens |